Many pills and transformations in X-Change Life come with temporary lasting effects. Below is a list of side effects that can be gained from a variety of sources:

• Live-In Maid – a side effect of the Ready-Maid™ pill by the WANGL corporation, can be acquired either doing the Ready-Maid sales demo (random chance), or by ignoring chores while male, in which case your stepdad gives you the pill in a sequence of 3 scenes. On the 3rd scene, the side effect is permanent. Essentially it means if you’re asked to do chores, you’ll be compelled to do them, and may gain arousal from each cleaning action.
• People Pleaser – a side effect of the Hot n’ Ready™ pill by the SWP corporation, can be acquired by doing the Hot n’ Ready demo and losing charm stats in the post-demo “survival mode”. You need to play the demo at least twice to get this mode. The side effect will make it harder to turn down requests, for instance if an NPC asks for you a blowjob, you won’t be able to convince him to go down on you instead – you’ll want to make him happy! Also obtainable from the New-U and not managing your compulsions.
• Brainless Bimbo – a side effect of the Dumb Bitch™ pill by the SWP corporation, can be acquired by doing the product demo, and hitting 1 Intellect. It will make the player freeze up at inconvenient times, like when they’re trying to reject a guy, for example. Also obtainable from the New-U and X-Change Bimbo pill.
• Swallow or it’s permanent – a side effect of the New-U machine, if you don’t swallow at least 1 load of cum a day, you’ll be stuck in your new DNA, even when you turn back to being a male.
• Orgasm or it’s permanent – a side effect of the New-U machine, if you don’t orgasm at least once per day, you’ll be stuck in your new DNA, even when you turn back to being a male.
• Swallow to continue – a side effect of the New-U machine, if you don’t swallow at least 1 load of cum a day, your transformation will wear off early.
• Orgasm to continue – a side effect of the New-U machine, if you don’t orgasm at least once per day, your transformation will wear off early.
• Submissive pleasure – a side effect of the New-U machine, you will receive a lot more pleasure in passive positions – this is a con in the Gym scenes, where orgasming in passive positions will sap all your energy.
• Libido overdrive – a side effect of the New-U machine, you will receive random increases of arousal which will make it harder to turn guys down.
• Breeder effects – a side effect of the New-U machine, as well as it’s own separate pill, you will not be able to orgasm without a creampie. Your chances of pregnancy are more than doubled, and after giving birth it will take longer to revert to being a male.
• Softened Physique – a side effect you can get from the Secretary pill, if you orgasm 5 times or more. It limits your maximum fitness.
• Mommy Milkers – You lactate, regardless of pregnancy. Obtainable from failing the Dairy Queen demo, beginning your transition to another life.
• Gulp n’ Shrink – Swallowing cum will shrink your dick. Obtainable from the New-U.
• Breeder’s Bane – Getting creampied will shrink your dick. Obtainable from the New-U.
• Shrinkgasm – Cumming will shrink your dick. Obtainable from the New-U.
• Get creampied or it’s permanent – You must get creampied at least once daily, or this DNA becomes permanent. Obtainable from the New-U.
• Get creampied to continue – You must get creampied daily, or your New-U transformation will expire the next day. Obtainable from the New-U.
• Resistance – Orgasms may extend your transformation and cause side effects. Obtainable from the New-U and X-Change Resistance pill.
• Exhibitionist – You enjoy displaying your body, and find it difficult to do otherwise. Obtainable from the New-U, the X-Change Show-Off pill, the X-Change Bimbo pill, or following the game’s stripper route.
• Swallowing makes you stupid – Swallowing cum will decrease your intellect. Obtainable from the New-U.
• Breed me dumber – Getting creampied will decrease your intellect. Obtainable from the New-U.
• Cum n’ Dumb – Cumming will decrease your intellect. Obtainable from the New-U.
• Soft after swallowing – Swallowing cum will decrease your fitness. Obtainable from the New-U.
• Breed me weaker – Getting creampied will decrease your fitness. Obtainable from the New-U.
• Cum so soft – Cumming will decrease your fitness. Obtainable from the New-U.
• Arousal is bad – Extreme arousal lowers your Charm xp gain. Obtainable from the New-U.